Research

Hematopathology Scholarly Activity

2022

Peer-Reviewed Articles:

Huang SL, *T Fennell , X Chen, JZ Huang. The pattern and diagnostic significance if the lack of surface immunoglobulin light chain on mature B-cells in clinical samples for lymphoma workup. Wileyonlinelibrary.com/journal/cytob. Clinical cytometry. 2022:1-8.

Habib PM, Serena T, Flynn CM, Hartkop A, Wey E, Lang D, Laveroni E. Incidental pathogenic fibrin-associated diffuse large B-cell lymphoma found during aorto-biiliac bypass. Cureus, 2022; 14(3): e23681.

Abstracts with Associated Research Presentations:

Mathew Trini, George Julie, Yost Christine N, Deebajah Mustafah, Johnson Paul, Huang James, Carpenter Christopher, Procalcitonin and D-dimer levels at baseline, but not CRP, were informative of COVID-19 hospitalization outcomes. Presented at ID week, October 19-23, 2022, Washington DC.

Boyer D, Perry A, Wey E, Hsueh J, Zhang W, Song J. Fibrin-associated diffuse large B-cell lymphoma shows frequent mutations related to immune surveillance and PTEN. European Association for Haematopathology-Society for Hematopathology 21st Meeting, Florence, Italy, September 2022 (abstract submitted, EAHP22-ABS-1615)

Book or Chapters:

Micale MA, Williams JL, Dinda S, Rivard S (2023): The biological basis and diagnostic evaluation of cancer. In Oncology Rehabilitation: A Comprehensive Guidebook for Clinicians. Elsevier

2021

Peer Reviewed Articles:

Anusim N, Douglas‐Nikitin V, Jaiyesimi I. Pernicious anemia presenting as pancytopenia. eJHaem. 2021 Nov;2(4):861-2.

Madanat L, Schoenherr D, Wey E, Gupta R. Rasburicase-induced haemolysis and methemoglobinemia: An ongoing issue. BMJ Case Rep. 2021 Mar 16;14(3):e240967. doi:10.1136

Abstracts with Associated Research Publications:

Qu Z, Qu E, Huang J, Micale MA, Li E. Utilization of 2D barcode technology to create surgical pathology reports. Am Clin Path 2021 Oct;156(S1):S116. doi.org/10.1093/ajcp/aqab191.247.

2020

Peer Reviewed Articles:

Micale M, Qu Z, Blake Martin. Machine learning can identify abnormal chromosomes to facilitate initial screening in the cytogenomics laboratory. Archives of Pathology & Laboratory Medicine, September 2020:144(9s1).

Wu J, Deebajah M, Lai Z, Micale M, Yu L. Utilization of deep neural network in recognition of BCR/ABL gene rearrangements in fluorescence in situ hybridization images. USCAP 109th Conference, Los Angeles, CA, February 2020.

2019

Peer-Reviewed Articles:

Gupta A, *Gabbard A, Smith MD, Micale M, Boyanton B, Huang J. Biclonal splenic marginal zone lymphoma with T-cell rich background and aggressive transformation to large cell lymphoma, Journal of Hematopathology, April 5, 2019;12:91-98.

Yin W, *Kumar T, Lai Z, Zeng X, Kanaan HD, Li W, et al. Kidney injury moelcule-1 can be used to predict renal functional recovery in native renal biopsies. Int Urol Nephrol, October 23, 2019.

Ysunza PA, Rontal M, Micale M. Occult subtotal cleft of the secondary palate with VPI associated with 8q22.2 deletion. International Journal of Pediatric Otorhinolaryngology, 124:54-58, September 2019.

2018

Peer-Reviewed Articles:

Lai Z, Kumar T, Zhao R, Li W, Kanaan H, Zhang PL, Liu B. Monoclonal Gammopathy of Renal Significance and its Associated Experimental Models: A Brief Review. Annals of Clinical & Laboratory Science. March 2019.(Online)

Cousineau C, Kumar T, Roszka JP, Lewinski KL, Li W, Kanaan HD, et al, [Zhang PL]. There Is high sensitive and specific correlation between frozen and permanent sections in renal transplant biopsies. Transplant Proc. 2018 Dec;50(10):3473-3477.

Yin W, Kumar T, Lai Z, Zeng X, Kanaan H, Li W, Bonventre J, Zhang P. Kidney Injury Moelcule-1, A Sensitive Marker for Identifying Acute Tubular Injury, Can Be Used to Predict Renal Functional Recovery in Native Renal Biopsies. Submitted

Ward N, Baqai J, Zehnpfennig A, Fine N, Huang J, Smith MD. Bcl-2 maturation pattern in t-cells distinguishes thymic neoplasm/hyperplasia, t-lymphoblastic lymphoma, and reactive lymph nodes. Cytometry Part B Clin Cytom. 2018 May;94(3):444-450.

Invited Research Presentations:

Tripti Kumar, Anthony Chang, Ping L. Zhang. Myeloperoxidase Identifies Glomerular Endothelial Injury in Renal Diseases with Complement Activation. The United States and Canadian Academy of Pathology (USCAP) Annual Meeting, Washington D.C., March 18-21, 2019, Platform Presentation

Kumar T, Boyantan B. Plasmablastic Lymphoma. 27th Annual Symposium on Molecular Pathology: Clinical Applications of Genomic Medicine. Troy, MI. September 12-13th, 2018. (Podium Presentation)

Gupta A, Smith M, Huang J. Identification of aggressive variants of mantle cell lymphoma based on flow cytometry. The United States and Canadian Academy of Pathology (USCAP) Annual Meeting, Vancouver, Canada, March 17-23, 2018.

Huang J, Rayborn B, Bernacki K, Young M. Introducing laboratory medicine to medical students before they enter clinical clerkship. Oakland University William Beaumont School of Medicine’s Experience, Association of Pathology Chairs Annual Meeting, San Diego, CA, July 14-17, 2018.

Huang J. Teaching medical students choosing wisely in diagnostic medicine clerkship. Oakland University William Beaumont School of Medicine’s Experience. Association of Pathology Chairs Annual Meeting, San Diego, CA, July 15-19, 2018.

Zhao J, VanHulle R, Misra L, Rasmussen C, Huang J. Outcome assessment of OUWB diagnostic medicine clerkship. OUWB 7th Annual William Davidson Medical Education Week, Rochester Hills, MI, May 14-18, 2018.

2017

Peer Reviewed Articles:

Ezekwudo DE, Ifabiyi T, Gbadamosi B, Haberichter K, Yu Z, Amin M, et al. Breast implant-associated anaplastic large cell lymphoma: A case report and review of the literature. Case Rep Oncol Med, published online October 31, 2017. 
2017;2017:6478467. doi: 10.1155/2017/6478467. Epub 2017 Oct 31. PMID: 29225983 https://www.ncbi.nlm.nih.gov/pubmed/29225983

Haberichter KL, *Crisan D. Green neutrophilic inclusions and acute hepatic failure: Clinical significance and brief review of the literature. Ann Clin Lab Sci. 2017 Jan;47(1):58-61. 
Review. PMID: 28249918. https://www.ncbi.nlm.nih.gov/pubmed/28249918

Haberichter KL, Johnson PC, Chittick PJ, Millward P, Robinson-Dunn, Boyanton BL Jr. The brief case: False-positive rapid malaria antigen test results in a returned traveler. J Clin Microbiol. 2017 Aug;55(8):2294-2297.

Haberichter KL, Johnson PC, Chittick PJ, Millward P, Robinson-Dunn, Boyanton BL Jr. Closing the brief case: False-positive rapid malaria antigen test results in a returned traveler. J Clin Microbiol 2017. Aug;55(8):2560-2561.

Hajj-Hussein I, Toushan M, Amin M, Blenc AM. Integrative approach for teaching histology and histopathology of the gastrointestinal tract using an IBD case. Histol Cytol Embryol. 2017;1:1-5.

Micale MA, Embrey B IV, Hubbell K, Beaudry-Rogers K, Whitten A. Prenatal identification of two discontinuous maternally inherited chromosome 7q36.3 microduplications totaling 507 kb including the sonic hedgehog gene in a fetus with multiple congenital anomalies. Clin Case Rep. 2017 May;5(6): 993-999. 
28588853

Micale MA, Powers S*, Embrey B, Williams J, Burroughs M, Huang JZ. Significant cytogenomic evolution identified by SNP chromosome microarray analysis accompanies plasmablastic transformation of a hyperdiploid plasma cell myeloma. J Hematopathol 2017. 10:133.

Ogunleye F, Huang JZ, Ibrahim M, Allen E, Brennan N, Yu Z, et al. Reply to SE Langabeer. J Oncol Prac. 2017 Apr 13(4):285-286. 
28195810

Ward N*, Baqai J*, Zehnpfennig A, Fine N, Huang JZ, Smith MD. Bcl-2 maturation pattern in t-cells distinguishes thymic neoplasm/hyperplasia, t-lymphoblastic lymphoma, and reactive lymph nodes. Cytometry B Clin Cytom, published online July 17, 2017. https://www.ncbi.nlm.nih.gov/pubmed/28718205 

Yu Z, Pang Y, Wang L, Ezekwudo DE, Ogunleye F, Gaikazian SS, et al, [Micale M, Huang JZ, Blenc AM]. Unusual presentation of a small-cell variant of anaplastic large-cell lymphoma case: When a septic picture is not sepsis. Case Rep Hematol, published online September 24, 2017. 
7292148. 1/2017 PMID: 29147592

Posters and Published Abstracts:

Chon C, Gjorgova-Gjeorgjievski S, Haberichter KL, Boyanton Jr BL, Fennell T. Acute myeloid leukemia with BCR-ABL1: A rare hematologic malignancy. Summer Internship Poster Presentation. OUWB School of Medicine, Rochester, MI, August 2017.

Cousineau C, Douglas-Nikitin V, Posey YF, Sykes E. Primary adrenal lymphoma presenting with severe hyponatremia. American Society for Clinical Pathology (ASCP) Annual Meeting, Chicago, IL, September 6-8, 2017. 
Poster Presentation,

*Roquiz W, Huang JZ. Rapid diagnosis of aggressive mature BNHL based on graphic presentation and statistic descriptions of FSC parameters by flow cytometry. The United States and Canadian Academy of Pathology (USCAP) Annual Meeting, San Antonio, TX, March 4-10, 2017.
Poster.

Shen Y, Huang JZ, Liu B, Zhang PL. GRP94, a chaperone protein, represents a new target for treating multiple myeloma. The United States and Canadian Academy of Pathology (USCAP) Annual Meeting, San Antonio, TX, March 4-10, 2017.
Poster (Abstract # 1511).

Thapar K, Karabon P, Smith MD. Utility and application of laboratory consultation for antiphospholipid Antibody: The William Beaumont Hospital experience. International Society of Laboratory Hematology Annual Meeting, Honolulu, HI, May 4-8, 2017. Poster.

2016

Peer Reviewed Articles:

David JA, Huang JZ. Diagnostic utility of flow cytometry analysis of reactive T cells in nodular lymphocyte-predominant Hodgkin lymphoma. Am J Clin Pathol. 2016 Jan;145(1):107-15. 26712878

Edupuganti S, Xie C, Huang JZ, Chen X, Wey E, Xie M. Clinicopathological features of primary bone marrow mature T and NK cell neoplasms. J J Cancer Sci Res. 2016; 2(7):046.

Gjeorgjievski M, Makki I, Khanal P, Amin MB, Blenc AM, Desai T, Cappell MS. Early, isolated duodenal mucosa-associated lymphoid tissue lymphoma presenting without symptoms or grossly apparent endoscopic lesions and diagnosed by random duodenal biopsies. Case Rep Gastroenterol. 2016 Jun 27;10(2):323-31.    6/2016 27482191.

*Haberichter K, Crisan D, Micale MA. ALK-negative anaplastic large T-cell lymphoma with a complex karyotype and DUSP22 gene rearrangement. CAP Today 2016;30(9), 49-54.

Huang JZ, Braziel RM, Fan G, Staudt LM and Chan WC. The Diagnostic Significance of Immunoglobulin Light Chain Gene Expression Signatures by Gene Expression Profiling for B-Cell Lymphoma2016. Remedy Open Access – Pathology 2016 26 Jul, 2016,1:Article 1010

Leeborg N, Loriaux M and Huang JZ. Aggressive T-cell Large Granular Lymphocytic Leukemia Presenting as an EBV Negative Post-Transplant Lymphoproliferative Disorder. Clinics in Oncology. 2016 May 30,1:Article 1007

Micale MA, Embrey B IV, Macknis JK, Harper ED, Aughton DJ. Constitutional 560.49 kb chromosome 2p24.3 duplication including the MYCN gene identified by SNP chromosome Microarray analysis in a child with multiple congenital anomalies and bilateral Wilm’s tumor. Eur J Med Genet. 2016 Oct 26;59(12):618-23.     Pii: S1769-7212(16)30119-7.

Ogunleye F, Ibrahim M, Allen E, Brennan N, Huang J, Yu J, Huben M and Jaiyesimi I. BCR-ABL Testing by Polymerase Chain Reaction in Patients With Neutrophilia: The William Beaumont Hospital Experience and the Case for Rational Laboratory Test Requests. Journal of Oncology Practice 12, no. 12 (December 2016) e1001-e1005.

Tagami T, Alhalabi O, *Ward N; Huang J, Paraneoplastic Dermatosis in a Patient with Anaplastic Large Cell Lymphoma:Case Report and Literature Review. Dermatopathology, 2016;3:39-43.

Yu Z, Ogunleye F, Blankenship LM, Ward N, Ezekwudo DE, Stender M, Gaikazian SS, Huang JZ and Jaiyesimi I:  Plasma Cell Leukemia Presenting with SpontaneousTumor Lysis Syndrome: Report of a Rare Case and Literature Review.  Ann of Hematol & Oncol 2016 3(12), id 1125

Book Chapter or Full Book Publications:

Cunningham MT and Smith MD. “Prolonged Prothrombin Time.” An algorithmic approach to hemostasis testing. 2nd ed. Kandice Kottke-Marchant. Illinois: College of American Pathologists, 2016. 173-194.

Huang JZ, Chen N, and Press R.  Molecular Methodologies and Molecular Pathology of Hematolymphoid Neoplasms. In: Cheng, L, Bostwick, DG, eds, Essentials of Anatomic Pathology. 4nd ed. Springer, 2016. 

Kottke-Marchant K and Smith MD. “The value of consultation in hemostasis testing.” An algorithmic approach to hemostasis testing. 2nd ed. Kandice Kottke-Marchant. Illinois: College of American Pathologists, 2016. 357-372.

Smith MD and Chandler WL. “Fibrinolysis System Physiology.” An algorithmic approach to hemostasis testing. 2nd ed. Kandice Kottke-Marchant. Illinois: College of American Pathologists, 2016. 33-42.

Smith MD and Moser KA. “Heparin induced thrombocytopenia.” An algorithmic approach to hemostasis testing. 2nd ed. Kandice Kottke-Marchant. Illinois: College of American Pathologists, 2016. 317-326.

Abstracts with Associated Research Presentations:

Edupuganti S, Xie C; Huang JZ, Chen X, Wey E. Xie M. Clinicopathological features of primary bone marrow mature T and NK cell neoplasms. College of American Pathologists (CAP) Annual Meeting, Las Vegas, NV, September 25-28, 2016.

Feng J, Zhang PL, Hysell CK, Qu ZH, Micale MA. Definitive cytogenetic confirmation of a desmoplastic small round cell tumor (DSRCT) in a initially unclassifiable malignant epithelioid neoplasm of small bowel of a 20 year old man: A case report. American Society of Clinical Pathology (ASCP) Annual Meeting, Las Vegas, NV, September 14-16, 2016.  (poster).

*Gabbard A, **Singh R, *Toushan M, Boyanton B, Smith MD, Huang J. Biclonal splenic marginal zone lymphoma, T-cell rich variant. College of American Pathologists (CAP) Annual Meeting, Las Vegas, NV, September 25-28, 2016. 

*Haberichter K, Huang S, Huang J.  Flow cytometry analysis of recurrent or persistent lymphadenopathy in patients with nodular lymphocyte predominant Hodgkin lymphoma. Presented as a poster at 31st International Clinical Cytometry Meeting, Bonita Springs, FL, 2016

Huang J. A New Active Learning Activity in Pathology Rotation of Diagnostic Medicine Clerkship:   Complete a Death Certificate and Present at Diagnostic Morbidity and Mortality Conference, Presented as a poster at Association of Pathology Chairs Annual Meeting, San Diego, CA,  July 12-15, 2016

**Singh R, Chen C, Huang J, Smith MD. Plasma cell myeloma: Impact of bone marrow erythropoiesis on prognostic markers. College of American Pathologists (CAP) Annual Meeting, Las Vegas, NV, September 25-28, 2016. 

**Singh RI, *Gabbard A, Micale M, Huang J, Smith MD. Concurrent bone marrow involvement by plasma cell myeloma and mantle cell lymphoma: A rare finding. College of American Pathologists (CAP) Annual Meeting, Las Vegas, NV, September 25-28, 2016. 

Thompson BJ, Barremkala M, Raoof A, Attardi S, Blenc A, Hajj-Hussein I, Forbes W, Gould D, Venuti J. Use of an Anatomy eBook To Document and Discuss Anatomical Variation. American Association of Anatomists Annual Meeting, Experimental Biology, San Diego CA 2016. 

*Toushan M, Zhang PL, Hysell CK, Kannan HD, Micale MA. Effective cytogenetic diagnosis of synovial sarcoma on touch preparation slides proves to be time/cost-effective. American Society of Clinical Pathology (ASCP) Annual Meeting, Las Vegas, NV, September 14-16, 2016.  case report (poster).

Posters and Published Abstracts:

Micale MA, Embrey B, Hubbell K, Beaudry-Rodgers K, Whitten A.  Prenatal identification of two discontinuous maternally-inhertited chromosome 7q36.3 microduplications totalling 507kb including the SHH gene in a fetus with multiple congenital anomalies. American College of Medical Genetics and Genomics Annual Meeting, Tampa, FL, March 8-12, 2016.

Ogunleye F, Ibhahim M, Blackenship L, Yadav S, Micale MA, Dougles V, Ifabiyi T, Anderson J, Stender M, Huben M, Quiroz E, Gaikazian S, Jaiyesimi I.  Analysis of genomic aberrations and its impact on survival in patients with chronic lymphocytic leukemia (CLL) at Beaumont Hospital Cancer Center. American Society of Hematology (ASH) Meeting on Hematologic Malignancies, Chicago, IL September 16-17, 2016.

Zhang PL, Hysell CK, Kanaan HD, Micale MA. The effective use of molecular cytogenetic (FISH) analysis on touch preparation slides permits a timely diagnosis of synovial sarcoma: Lessons learned. American Society of Clinical Pathology (ASCP) Annual Meeting, Las Vegas, NV, September 14-16, 2016.

Zhang PL, Hysell CK, Qu ZH, Micale MA. Definitive cytogenetic confirmation of a desmoplastic small round blue cell tumor (DSRCT) in the small bowel of 20-year-old man. American Society of Clinical Pathology (ASCP) Annual Meeting, Las Vegas, NV, September 14-16, 2016.   Case report.

2015

Peer reviewed articles:

Bostic G, Thompson R, Atanasoski S, Canlas C, Ye H, Kolins M, Smith MD. Quality improvement in the coagulation laboratory: reducing the number of insufficient blood draw specimens for coagulation testing. Lab Med 2015; 46:347-355. HIC# 2014-277.

*Cotrell A, **Sayedian F, Huang M, Chen X, Xie M, Smith MD, Huang JZ. Flow cytometric analysis of cell size in B-cell non-Hodgkin lymphoma: reliability and potential diagnostic significance. Int J Pathol Clin Res 2015; 1:1-6. HIC# 09-096.

David JA , Huang JZ. Diagnostic Utility of Flow Cytometry Analysis of Reactive T-cells in Nodular Lymphocyte-Predominant Hodgkin Lymphoma, Am J Clin Pathol 2016;145:107-115. HIC# 2013-175
**Kumar T, Fennell T, Zhang PL. Eighteen-months may be a reliable storage period for direct immunofluorescent slides of renal biopsies at room temperature. J Clin Nephrol Ren Care. 2015, 1:1-5. HIC: 2012-109

Smythe MA, Forsyth LL, Warkentin TE, Smith MD, Sheppard JI, Shannon F. Progressive, fatal thrombosis associated with heparin-induced thrombocytopenia following cardiac surgery despite “therapeutic” anticoagulation with argatroban: potential role for PTT and ACT confounding. J Cardiothoracic and Vasc Anes 2015; 29(5):1319-21. (Based on case report; no HIC review required)

Abstracts/Posters:

**Cosner, D, Uzieblo A, Nelson ML, Blenc AM, Fennell T.Blastic Plasmacytoid Dendritic Cell Neoplasm. American Society of Dermatopathology, San Francisco, CA, October 8-11, 2015 (poster presentation).

**Haberichter K, Crisan D. Green neutrophilic inclusions and acute hepatic failure. Arch. Pathol. Lab. Med. 139; pubished online, 2015. Poster at CAP Annual Meeting, Nashville, TN, October 4-7, 2015.

Hajj Hussein I, Barremkala M, Thompson B, Gould D, Hankin M, Forbes W, Blenc AM, Amin M, Venuti J. Integrating Histology, Gross Anatomy and Histopathology in a Case Based Approach to Inflammatory Bowel Disease. Experimental Biology, Boston, MA, March 28 – April 1, 2015 (oral presentation).

Huang JZ, Young MR, Misra L, VanHulle R. Putting the Pieces Together: A Curriculum Designed to Integrate the Imaging and Laboratory Findings of a Symptomatic Patient.  Poster presentation at AAMC CGSA/CGEA Joint Regional Meeting, Columbus, OH, April 9-12, 2015. HIC# NA.

Huang JZ.  Assessment of 4th Year Medical Student’s Competency in Diagnostic Workup for Anemia and Lymphadenopathy Prior to Diagnostic Medicine Clerkship. Poster presentation in OUWB 4th Annual William Davidson Medical Education Week, Birmingham MI, May 18-20, 2015. HIC# NA.

Huang JZ.  Mandatory Pathology Rotation within Diagnostic Medicine Clerkship for All Medical Students: Oakland University William Beaumont School of Medicine’s Experience, Oral Presentation at Association of Pathology Chairs 2015 Annual Meeting, San Diego, CA, July 14-17, 2015. HIC# NA

**Kumar T, Fennell T, Zhang PL. Eighteen-months may be a reliable storage period for direct immunofluorescent slides of renal biopsies at room temperature. ASCP Pathologist Meeting (poster), Oct 28 - Oct 30, 2015, Long Beach, CA HIC 2012-109.

Ogunleye F, Huang JZ, Mohammed I, Allen E, Brennan N, Jaiyesimi I. TX, Diagnostic Significance of Screening for BCR-ABL1 by PCR in Patients with Neutrophilia. The William Beaumont Hospital experience. Poster presentation at Society of Hematologic Oncology 2015 Annual Meeting, Houston, September 16-19, 2015. Proceedings of the Society of Hematologic Oncology 2015 Annual Meeting. Clinical Lymphoma Myeloma and Leukemia.2015; 15, S2:S33. HIC# 2014-314

*Sikdar S, Prada A, Crisan D. Calreticulin mutation in JAK2 V617F negative myeloproliferative neoplasms - The Beaumont experience. Modern Pathology 28: Suppl 2, 378, 2015. Poster at USCAP Annual Meeting, Boston, MA, March 21-27, 2015. HIC-2014-234